Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells.Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein.We encountered a case of a feline 1-hcpch vaccine 45-year-old female with loss of vision in the left eye.
She had a history of trauma to that eye two years ago.Enucleation was carried out, because malignancy was suspected due to retinal calcification.On the basis of light microscopy and merlin wizard costume immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.